서울대학교 약학과 창동신 교수 연구실

박지원 Ji Won Park

석•박사통합과정, 2020 ~

Jang J, Yu H, Oh EB, Park JW, Kim S, Kim T, Sohn J, Jin BR, Chang TS. Targeting NADPH Oxidase with APX-115: Suppression of Platelet Activation and Thrombotic Response. Antioxid Redox Signal 2025. [Link to Article]

Park JW, Sonn SK, Lee B-H, Oh GT, Chang T-S. Peroxiredoxin Ⅲ mitigates mitochondrial H2O2-mediated damage and supports quality control in cardiomyocytes under hypoxia-reoxygenation stress. Redox Biology 2025;86:103799. [Link to Article]

*Zheng R, *Park JW, Oh EB, Chang T-S, Chin Y-W. Chemical Constituents from the Leaves of Eruca sativa (Rocket Salad) Exhibiting Dual Cardioprotective and Antiplatelet Activities. ACS Omega 2025. (*co-first author) [Link to Article]

*Oh EB, *Shin HJ, Yu H, Jang J, Park JW, Chang TS. NADPH oxidase 1/4 dual inhibitor setanaxib suppresses platelet activation and thrombus formation. Life Sci. 2024;357:123061. (*co-first author) [Link to Article]

*Kim SR, *Park JW, Choi YJ, Sonn SK, Oh GT, Lee BH, Chang TS. Mitochondrial H2O2 Is a Central Mediator of Diclofenac-Induced Hepatocellular Injury. Antioxidants. 2024; 13(1):17. (*co-first author) [Link to Article]

Kim SR, Park JW, Lee BH, Lim KM, Chang TS. Peroxiredoxin V Protects against UVB-Induced Damage of Keratinocytes. Antioxidants (Basel). 2023 Jul 16;12(7). [Link to Article]

오은비 Eun Bee Oh

박사과정, 2025 ~

석사과정, 2023 ~ 2025

Study on dual-active A2A/A3 adenosine receptor agonist LJ-4715: application as a therapeutic agent for cardiovascular diseases

Jang J, Yu H, Oh EB, Park JW, Kim S, Kim T, Sohn J, Jin BR, Chang TS. Targeting NADPH Oxidase with APX-115: Suppression of Platelet Activation and Thrombotic Response. Antioxid Redox Signal 2025. [Link to Article]

Zheng R, Park JW, Oh EB, Chang T-S, Chin Y-W. Chemical Constituents from the Leaves of Eruca sativa (Rocket Salad) Exhibiting Dual Cardioprotective and Antiplatelet Activities. ACS Omega 2025. [Link to Article]

*Oh EB, *Shin HJ, Yu H, Jang J, Park JW, Chang TS. NADPH oxidase 1/4 dual inhibitor setanaxib suppresses platelet activation and thrombus formation. Life Sci. 2024;357:123061. (*co-first author) [Link to Article]

김태령 Taeryeong Kim

석사과정, 2024 ~

Jang J, Yu H, Oh EB, Park JW, Kim S, Kim T, Sohn J, Jin BR, Chang TS. Targeting NADPH Oxidase with APX-115: Suppression of Platelet Activation and Thrombotic Response. Antioxid Redox Signal 2025. [Link to Article]

김소리 Solee kim

석사과정, 2024 ~

Jang J, Yu H, Oh EB, Park JW, Kim S, Kim T, Sohn J, Jin BR, Chang TS. Targeting NADPH Oxidase with APX-115: Suppression of Platelet Activation and Thrombotic Response. Antioxid Redox Signal 2025. [Link to Article]

손지수 Jisue Sohn

석박통합과정, 2024.09~

Jang J, Yu H, Oh EB, Park JW, Kim S, Kim T, Sohn J, Jin BR, Chang TS. Targeting NADPH Oxidase with APX-115: Suppression of Platelet Activation and Thrombotic Response. Antioxid Redox Signal 2025. [Link to Article]

김신리 Sin Ri Kim

석•박사통합과정, 2016 - 2024

Protective role of mitochondrial specific peroxiredoxins against oxidative stress

현재 KISTEP 한국과학기술기획평가원

*Kim SR, *Park JW, Choi Y-J, Sonn SK, Oh GT, Lee B-H, Chang T-S. Mitochondrial H2O2 Is a Central Mediator of Diclofenac-Induced Hepatocellular Injury. Antioxidants. 2024; 13(1):17. (*co-first author) [Link to Article]

Kim SR, Park JW, Lee BH, Lim KM, Chang TS. Peroxiredoxin V Protects against UVB-Induced Damage of Keratinocytes. Antioxidants (Basel). 2023 Jul 16;12(7).

doi: 10.3390/antiox12071435. PubMed PMID: 37507973.

Baek, J.Y., Park, S., Park, J., Jang, J.Y., Wang, S.B., Kim, S.R., Woo, H.A., Lim, K.M., and Chang, T.S. (2017). Protective Role of Mitochondrial Peroxiredoxin III against UVB-Induced Apoptosis of Epidermal Keratinocytes. J Invest Dermatol 137, 1333-1342. [Link to Article]

Jung, S.H., Lee, W., Park, S.H., Lee, K.Y., Choi, Y.J., Choi, S., Kang, D., Kim, S.R., Chang, T.S., Hong, S.S., and Lee, B.H. (2020). Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity. Redox Biology 37, 101751. [Link to Article]

왕수빈 Su Bin Wang

석•박사통합과정, 2012 - 2016

Studies on (1) the antiplatelet mechanism of action of a novel PPARγ agonist and (2) the antithrombogenic role of peroxiredoxin II in hyperlipidemic state

현재 LG Chem Co., Ltd.

Wang, S.B., Jang, J.Y., Chae, Y.H., Min, J.H., Baek, J.Y., Kim, M., Park, Y., Hwang, G.S., Ryu, J.S., and Chang, T.S. (2015). Kaempferol suppresses collagen-induced platelet activation by inhibiting NADPH oxidase and protecting SHP-2 from oxidative inactivation. Free Radic Biol Med 83, 41-53. [Link to Article]

*Jang, J.Y., *Min, J.H., Wang, S.B., Chae, Y.H., Baek, J.Y., Kim, M., Ryu, J.S., and Chang, T.S. (2015). Resveratrol inhibits collagen-induced platelet stimulation through suppressing NADPH oxidase and oxidative inactivation of SH2 domain-containing protein tyrosine phosphatase-2. Free Radic Biol Med 89, 842-851. (*co-first author) [Link to Article]

Yoon JS, Kim G, Jarhad DB, Kim HR, Shin YS, Qu S, Sahu PK, Kim HO, Lee HW, Wang SB, Kong YJ, Chang TS, Ogando NS, Kovacikova K, Snijder EJ, Posthuma CC, van Hemert MJ, Jeong LS. Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues. J Med Chem. 2019 Jul 11;62(13):6346-6362 [Link to Article]

백진영 Jin Young Baek

석사과정, 2006 - 2008, Protective Role of Sulfiredoxin in Oxidative Stress-induced Apoptosis

박사과정, 2008 - 2015, Redox control of cell death by peroxiredoxins

현재 선임연구원 @ 한국원자력의학원 방사선비임상센터

2015-2022 Post-doc @National Institute of Health, USA

Baek, J.Y., Han, S.H., Sung, S.H., Lee, H.E., Kim, Y.M., Noh, Y.H., Bae, S.H., Rhee, S.G., and Chang, T.S. (2012). Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H₂O₂. J Biol Chem 287, 81-89. [Link to Article]

*Yang, Y.J., *Baek, J.Y., Goo, J., Shin, Y., Park, J.K., Jang, J.Y., Wang, S.B., Jeong, W., Lee, H.J., Um, H.D., et al. (2016). Effective Killing of Cancer Cells Through ROS-Mediated Mechanisms by AMRI-59 Targeting Peroxiredoxin I. Antioxid Redox Signal 24, 453-469. (*co-first author) [Link to Article]

Baek, J.Y., Park, S., Park, J., Jang, J.Y., Wang, S.B., Kim, S.R., Woo, H.A., Lim, K.M., and Chang, T.S. (2017). Protective Role of Mitochondrial Peroxiredoxin III against UVB-Induced Apoptosis of Epidermal Keratinocytes. J Invest Dermatol 137, 1333-1342. [Link to Article]

장지용 Ji Yong Jang

석•박사통합과정, 2007 - 2012

Collagen-induced H₂O₂ generation regulates platelet activation through oxidation of SHP-2

현재 부장 @ Vasthera Co., Ltd

2014-2020 Post-doc @ University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

2012-2013 Post-doc @National Institute of Health, USA

Jang, J.Y., Min, J.H., Chae, Y.H., Baek, J.Y., Wang, S.B., Park, S.J., Oh, G.T., Lee, S.H., Ho, Y.S., and Chang, T.S. (2014). Reactive oxygen species play a critical role in collagen-induced platelet activation via SHP-2 oxidation. Antioxid Redox Signal 20, 2528-2540. [Link to Article]

Jang, J.Y., Min, J.H., Wang, S.B., Chae, Y.H., Baek, J.Y., Kim, M., Ryu, J.S., and Chang, T.S. (2015). Resveratrol inhibits collagen-induced platelet stimulation through suppressing NADPH oxidase and oxidative inactivation of SH2 domain-containing protein tyrosine phosphatase-2. Free Radic Biol Med 89, 842-851. [Link to Article]

Jang, J.Y., Wang, S.B., Min, J.H., Chae, Y.H., Baek, J.Y., Yu, D.Y., and Chang, T.S. (2015). Peroxiredoxin II is an antioxidant enzyme that negatively regulates collagen-stimulated platelet function. J Biol Chem 290, 11432-11442. [Link to Article]

*Wang, S.B., *Jang, J.Y., *Chae, Y.H., Min, J.H., Baek, J.Y., Kim, M., Park, Y., Hwang, G.S., Ryu, J.S., and Chang, T.S. (2015). Kaempferol suppresses collagen-induced platelet activation by inhibiting NADPH oxidase and protecting SHP-2 from oxidative inactivation. Free Radic Biol Med 83, 41-53. (*co-first author) [Link to Article]

노유현 You Hyun Noh

석•박사통합과정, 2006 - 2010

Protective role of Peroxiredoxin III and Sulfiredoxin against mitochondrial H₂O₂-mediated damage in cardiomyocytes

현재 Senior Researcher @ Thermo Fisher Scientific Inc., USA

Noh, Y.H., Baek, J.Y., Jeong, W., Rhee, S.G., and Chang, T.S. (2009). Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III. J Biol Chem 284, 8470-8477. [Link to Article]

장조아라 Joara Jang

석사과정, 2022 ~ 2023

APX-115, a pan-NOX inhibitor, prevents platelet activation signaling via reducing ROS generation

현재 Shinpoong Pharm. Co., Ltd.

Jang J, Yu H, Oh EB, Park JW, Kim S, Kim T, Sohn J, Jin BR, Chang TS. Targeting NADPH Oxidase with APX-115: Suppression of Platelet Activation and Thrombotic Response. Antioxid Redox Signal 2025. [Link to Article]

Oh EB, Shin HJ, Yu H, Jang J, Park JW, Chang TS. NADPH oxidase 1/4 dual inhibitor setanaxib suppresses platelet activation and thrombus formation. Life Sci. 2024;357:123061. [Link to Article]

유현성 HyunSeong Yu

석사과정, 2022 ~ 2023

DG401, a new NOX2 inhibitor, suppresses collagen-induced platelet activation

현재 Celltrion Inc.

Jang J, Yu H, Oh EB, Park JW, Kim S, Kim T, Sohn J, Jin BR, Chang TS. Targeting NADPH Oxidase with APX-115: Suppression of Platelet Activation and Thrombotic Response. Antioxid Redox Signal 2025. [Link to Article]

Oh EB, Shin HJ, Yu H, Jang J, Park JW, Chang TS. NADPH oxidase 1/4 dual inhibitor setanaxib suppresses platelet activation and thrombus formation. Life Sci. 2024;357:123061. [Link to Article]

장세연 SeYeon Jang

석사과정, 2021 ~ 2022

Peroxiredoxin III prevents doxorubicin-induced cardiomyocyte injury by rescuing mitophagy

현재 대한민국 식품의약품안전처

김지은 Ji Eun Kim

석사과정, 2021 ~2022

Protective Role of Peroxiredoxin Ⅲ against hypoxia/reoxygenation induced Cardiomyocyte Damage

‌김미연 Mi Yeon Kim

석사과정, 2020-2021

Protective Role of Peroxiredoxin Ⅲ against Doxorubicin-induced Cardiomyocyte Damage

현재 Dong-A ST. Co., Ltd

‌신혜지 Hye Ji Shin

석사과정, 2018-2020

Studies on the antiplatelet activity of GKT137831 (Setanaxib), a NADPH oxidase inhibitor

*Oh EB, *Shin HJ, Yu H, Jang J, Park JW, Chang TS. NADPH oxidase 1/4 dual inhibitor setanaxib suppresses platelet activation and thrombus formation. Life Sci. 2024;357:123061. (*co-first author) [Link to Article]

‌공윤정 Yun Jeong Kong

‌석사과정, 2017 - 2020

Studies on the anti-platelet activity of GSK2795039, a NADPH oxidase inhibitor

현재 Daewoong Pharm. Co., Ltd

Yoon JS, Kim G, Jarhad DB, Kim HR, Shin YS, Qu S, Sahu PK, Kim HO, Lee HW, Wang SB, Kong YJ, Chang TS, Ogando NS, Kovacikova K, Snijder EJ, Posthuma CC, van Hemert MJ, Jeong LS. Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues. J Med Chem. 2019 Jul 11;62(13):6346-6362 ‌‌‌‌‌[Link to Article]‌‌‌

채윤희 Yun Hee Chae

석사과정, 2010 - 2011

Effects of Kaempferol on Reactive Oxygen Species (ROS)-mediated Platelet Activation

현재 AhnGook Pharmaceutical Co., Ltd.

한선희 Sun Hee Han

석사과정, 2009 - 2011

Protective role of sulfiredoxin in mouse embryonic fibroblast cells exposed to low steady-state levels of H₂O₂

Baek, J.Y., Han, S.H., Sung, S.H., Lee, H.E., Kim, Y.M., Noh, Y.H., Bae, S.H., Rhee, S.G., and Chang, T.S. (2012). Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H₂O₂. J Biol Chem 287, 81-89. [Link to Article]

손희연 Hee Yeon Shon

석사과정, 2007 - 2009

RANKL-induced oxidation of SHP-1 promotes osteoclast differentiation

현재 Roche Diagnostics Korea Co., Ltd.

민지현 Ji Hyun Min

석사과정, 2007 - 2009

Effects of Resveratrol on Reactive Oxygen Species-mediated Platelet Activations

현재 Boryung Pharmaceutical Co., Ltd.

*Jang, J.Y., *Min, J.H., Wang, S.B., Chae, Y.H., Baek, J.Y., Kim, M., Ryu, J.S., and Chang, T.S. (2015). Resveratrol inhibits collagen-induced platelet stimulation through suppressing NADPH oxidase and oxidative inactivation of SH2 domain-containing protein tyrosine phosphatase-2. Free Radic Biol Med 89, 842-851. (*co-first author) [Link to Article]

‌양연주 Yeon Ju Yang

석‌사연구원, 2007 - 2009

현재 Research Scientist@Yonsei University, Seoul, Republic of Korea

‌

Yang, Y.J., Baek, J.Y., Goo, J., Shin, Y., Park, J.K., Jang, J.Y., Wang, S.B., Jeong, W., Lee, H.J., Um, H.D., et al. (2016). Effective Killing of Cancer Cells Through ROS-Mediated Mechanisms by AMRI-59 Targeting Peroxiredoxin I. Antioxid Redox Signal 24, 453-469. ‌[Link to Article]

김유미 Yu-mi Kim

석사연구원, 2006 - 2009

현재 Korea MEDIPOST Co., Ltd.

Baek, J.Y., Han‌, S.H., Sung, S.H., Lee, H.E., Kim, Y.M., Noh, Y.H., Bae, S.H., Rhee, S.G., and Chang, T.S. (2012). Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H₂O₂. J Biol Chem 287, 81-89. [Link to Article]

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